C. Everett Koop, 'rock star' surgeon general, dies


NEW YORK (AP) — Dr. C. Everett Koop has long been regarded as the nation's doctor— even though it has been nearly a quarter-century since he was surgeon general.


Koop, who died Monday at his home in Hanover, N.H., at age 96, was by far the best known and most influential person to carry that title. Koop, a 6-foot-1 evangelical Presbyterian with a biblical prophet's beard, donned a public health uniform in the early 1980s and became an enduring, science-based national spokesman on health issues.


He served for eight years during the Reagan administration and was a breed apart from his political bosses. He thundered about the evils of tobacco companies during a multiyear campaign to drive down smoking rates, and he became the government's spokesman on AIDS when it was still considered a "gay disease" by much of the public.


"He really changed the national conversation, and he showed real courage in pursuing the duties of his job," said Chris Collins, a vice president of amfAR, the Foundation for AIDS Research.


Even before that, he had been a leading figure in medicine. He was one of the first U.S. doctors to specialize in pediatric surgery at a time when children with complicated conditions were often simply written off as untreatable. In the 1950s, he drew national headlines for innovative surgeries such as separating conjoined twins.


His medical heroics are well noted, but he may be better remembered for transforming from a pariah in the eyes of the public health community into a remarkable servant who elevated the influence of the surgeon general — if only temporarily.


"He set the bar high for all who followed in his footsteps," said Dr. Richard Carmona, who served as surgeon general a decade later under President George W. Bush.


Koop's religious beliefs grew after the 1968 death of his son David in a mountain-climbing accident, and he became an outspoken opponent of abortion. His activism is what brought him to the attention of the administration of President Ronald Reagan, who decided to nominate him for surgeon general in 1981. Though once a position with real power, surgeon generals had been stripped of most of their responsibilities in the 1960s.


By the time Koop got the job, the position was kind of a glorified health educator.


But Koop ran with it. One of his early steps involved the admiral's uniform that is bestowed to the surgeon general but that Koop's predecessors had worn only on ceremonial occasions. In his first year in the post, Koop stopped wearing his trademark bowties and suit jackets and instead began wearing the uniform, seeing it as a way to raise the visual prestige of the office.


In those military suits, he surprised the officials who had appointed him by setting aside his religious beliefs and feelings about abortion and instead waging a series of science-based public health crusades.


He was arguably most effective on smoking. He issued a series of reports that detailed the dangers of tobacco smoke, and in speeches began calling for a smoke-free society by the year 2000. He didn't get his wish, but smoking rates did drop from 38 percent to 27 percent while he was in office — a huge decline.


Koop led other groundbreaking initiatives, but perhaps none is better remembered than his work on AIDS.


The disease was first identified in 1981, before Koop was officially in office, and it changed U.S. society. It destroyed the body's immune system and led to ghastly death, but initially was identified in gay men, and many people thought of it as something most heterosexuals didn't have to worry about.


U.S. scientists worked hard to identify the virus and work on ways to fight it, but the government's health education and policy efforts moved far more slowly. Reagan for years was silent on the issue. Following mounting criticism, Reagan in 1986 asked Koop to prepare a report on AIDS for the American public.


His report, released later that year, stressed that AIDS was a threat to all Americans and called for wider use of condoms and more comprehensive sex education, as early as the third grade. He went on to speak frankly about AIDS in an HBO special and engineered the mailing of an educational pamphlet on AIDS to more than 100 million U.S. households in 1988.


Koop personally opposed homosexuality and believed sex should be saved for marriage. But he insisted that Americans, especially young people, must not die because they were deprived of explicit information about how HIV was transmitted.


Koop's speeches and empathetic approach made him a hero to a wide swath of America, including public health workers, gay activists and journalists. Some called him a "scientific Bruce Springsteen." AIDS activists chanted "Koop, Koop" at his appearances and booed other officials.


"I was walking down the street with him one time" about five years ago, recalled Dr. George Wohlreich, director of the College of Physicians of Philadelphia, a medical society with which Koop had longstanding ties. "People were yelling out, 'There goes Dr. Koop!' You'd have thought he was a rock star."


Koop angered conservatives by refusing to issue a report requested by the Reagan White House, saying he could not find enough scientific evidence to determine whether abortion has harmful psychological effects on women.


He got static from some staff at the White House for his actions, but Reagan himself never tried to silence Koop. At a congressional hearing in 2007, Koop spoke about political pressure on the surgeon general post. He said Reagan was pressed to fire him every day.


After his death was reported Monday, the tributes poured forth, including a statement from New York Mayor Michael Bloomberg, who has made smoking restrictions a hallmark of his tenure.


"The nation has lost a visionary public health leader today with the passing of former Surgeon General C. Everett Koop, who was born and raised in Brooklyn," Bloomberg said. "Outspoken on the dangers of smoking, his leadership led to stronger warning labels on cigarettes and increased awareness about second-hand smoke, creating an environment that helped millions of Americans to stop smoking — and setting the stage for the dramatic changes in smoking laws that have occurred over the past decade."


Dr. Anthony Fauci of the National Institutes of Health taught Koop what was known about AIDS during quiet after-hours talks in the early 1980s and became a close friend.


"A less strong person would have bent under the pressure," Fauci said. "He was driven by what's the right thing to do."


Carmona, a surgeon general years later, said Koop was a mentor who preached the importance of staying true to the science in speeches and reports — even when it made certain politicians uncomfortable.


"We remember him for the example he set for all of us," Carmona said.


Koop's nomination originally was met with staunch opposition. Women's groups and liberal politicians complained Reagan had selected him only because of his conservative views, especially his staunch opposition to abortion.


Foes noted that Koop traveled the country in 1979 and 1980 giving speeches that predicted a progression "from liberalized abortion to infanticide to passive euthanasia to active euthanasia, indeed to the very beginnings of the political climate that led to Auschwitz, Dachau and Belsen."


But Koop, a devout Presbyterian, was confirmed as surgeon general after he told a Senate panel he would not use the post to promote his religious ideology. He kept his word and eventually won wide respect with his blend of old-fashioned values, pragmatism and empathy.


Koop was modest about his accomplishments, saying before leaving office in 1989, "My only influence was through moral suasion."


The office declined after that. Few of his successors had his speaking ability or stage presence. Fewer still were able to secure the support of key political bosses and overcome the meddling of everyone else. The office gradually lost prestige and visibility, and now has come to a point where most people can't name the current surgeon general. (It's Dr. Regina Benjamin.)


Even after leaving office, Koop continued to promote public health causes, from preventing childhood accidents to better training for doctors.


"I will use the written word, the spoken word and whatever I can in the electronic media to deliver health messages to this country as long as people will listen," he promised.


In 1996, he rapped Republican presidential hopeful Bob Dole for suggesting that tobacco was not invariably addictive, saying Dole's comments "either exposed his abysmal lack of knowledge of nicotine addiction or his blind support of the tobacco industry."


He maintained his personal opposition to abortion. After he left office, he told medical students it violated their Hippocratic oath. In 2009, he wrote to Senate Majority Leader Harry Reid, urging that health care legislation include a provision to ensure doctors and medical students would not be forced to perform abortions. The letter briefly set off a security scare because it was hand delivered.


Koop served as chairman of the National Safe Kids Campaign and as an adviser to President Bill Clinton's health care reform plan.


Worried that medicine had lost old-fashioned caring and personal relationships between doctors and patients, Koop opened an institute at Dartmouth College in New Hampshire to teach medical students basic values and ethics. He also was a part-owner of a short-lived venture, drkoop.com, to provide consumer health care information via the Internet.


Koop was the only son of a Manhattan banker and the nephew of a doctor. He said by age 5 he knew he wanted to be a surgeon and at age 13 he practiced his skills on neighborhood cats. He attended Dartmouth, where he received the nickname Chick, short for "chicken Koop." It stuck for life.


He received his medical degree at Cornell Medical College, choosing pediatric surgery because so few surgeons practiced it. In 1938, he married Elizabeth Flanagan, the daughter of a Connecticut doctor. They had four children. Koop's wife died in 2007, and he married Cora Hogue in 2010.


He was appointed surgeon-in-chief at Children's Hospital in Philadelphia and served as a professor at the University of Pennsylvania School of Medicine. He pioneered surgery on newborns and successfully separated three sets of conjoined twins. He won national acclaim by reconstructing the chest of a baby born with the heart outside the body.


Although raised as a Baptist, he was drawn to a Presbyterian church near the hospital, where he developed an abiding faith. He began praying at the bedside of his young patients — ignoring the snickers of some of his colleagues.


___


Contributing to this report were Associated Press writers Wilson Ring in Montpelier, Vt.; Jeff McMillan in Philadelphia; and AP Medical Writer Lauran Neergaard in Washington.


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Boehner Pressures Dems to Get 'Off Their...'


Feb 26, 2013 12:48pm


House Speaker John Boehner used some choice words to pressure Senate Democrats to avert the looming sequester — $85 billion of arbitrary across-the-board cuts — insisting that “the House has done its job” and the burden to offer an alternative before the cuts strike Friday is on the president’s party.


“We have moved the bill in the House twice,” Boehner, R-Ohio, said. “We should not have to move a third bill before the Senate gets off their ass and begins to do something.”


House Republicans voted twice during the 112th Congress to narrowly pass legislation to offset sequestration with alternative savings, but those measures languished in the Senate and expired with the end of the session.


Read More About Sequestration


Boehner also criticized President Obama for taking a Virginia road trip “to use our military men and women as a prop in yet another campaign rally to support his tax hikes.”


ap john boehner gop leadership ll 130226 wblog Boehner Hopes Senate Gets Off Their Ass

J. Scott Applewhite/AP Photo


“I don’t think the president’s focused on trying to find a solution to the sequester,” he said. “For 16 months, the president’s been traveling all over the country holding rallies, instead of sitting down with Senate leaders in order to try to forge an agreement over there in order to move the bill.”


Considering Republicans have not acted in the current session of Congress on any legislation to replace the sequester, House Democrats question whether there is sufficient support to pass the old GOP proposal.


“I don’t think I need to give the Speaker a lesson in legislating or how government runs, but whatever was done last year that didn’t get signed into law has evaporated. It is gone. It does not exist,” California Democratic Rep. Xavier Becerra, the chairman of the House Democratic Caucus, said today. “This is a new year, a new session of Congress and it’s time for everyone to get to work.”


Boehner deflected a question whether he believes his weakened majority could pass the Republican bill again, and returned his attention to pushing for a vote in the Senate.


“It’s time for the Senate to act. It’s not about the House,” he responded. “We’ve acted.”


Related: Sequester Timeline – When Will Cuts Kick In?


“Where’s the president’s plan to avoid the sequester? Have you seen one? I haven’t seen one. All I’ve heard is that he wants to raise taxes again. Where’s the president’s plan? Where’s the Senate Democrat plan? I want to see it.”


Senate leaders are expected to introduce and vote on their respective plans later this week, perhaps by Thursday.


Senate Majority Leader Harry Reid accused Congressional Republicans of being “part of the problem” in finding a solution to the upcoming cuts, pressing for new tax increases to help offset the sequester.


“We want to work with Republicans to come to a balanced responsible way to reduce this sequester, the impact of it.  My republican colleagues are standing in the way,” Reid, D-Nev., said on the Senate floor. “They only want cuts and more cuts.”


Related: States Prepare for Sequester


Although Senate Minority Leader Mitch McConnell has said he is not interested in a last-minute deal, Boehner said “If the Senate acts, I’m sure the House will act quickly.”


The House is meeting for legislation business today, although no action to avert the sequester is expected. The House also meets Wednesday and Thursday, but is currently not expected to be in session on Friday.


ABC News’ Arlette Saenz contributed to this report


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Huge protest vote pushes Italy towards deadlock


ROME (Reuters) - A huge protest vote by Italians enraged by economic hardship and political corruption pushed the country towards deadlock after an election on Monday, with voting projections showing no coalition strong enough to form a government.


With more than two thirds of the vote counted, the projections suggested the center left could have a slim lead in the race for the lower house of parliament.


But no party or likely coalition appeared likely to be able to form a majority in the upper house or Senate, creating a deadlocked parliament - the opposite of the stable result that Italy desperately needs to tackle a deep recession, rising unemployment and a massive public debt.


Such an outcome has the potential to revive fears over the euro zone debt crisis, with prospects of a long period of uncertainty in the zone's third largest economy.


Italian financial markets took fright after rising earlier on hopes for a stable and strong center-left led government, probably backed by outgoing technocrat premier Mario Monti.


The projected result was a stunning success for Genoese comic Beppe Grillo, leader of the populist 5-Star Movement, who toured the country in his first national election campaign hurling obscenity-laced insults against a discredited political class.


With vague election promises and a team of almost totally unknown candidates, the shaggy haired comedian channeled pure public anger against what many see as a sclerotic and useless political system.


The likely result was also a humiliating slap in the face for colorless center-left leader Pier Luigi Bersani, who appeared to have thrown away a 10-point opinion poll lead less than two months ago against Silvio Berlusconi's center right.


Berlusconi, 76, who staged an extraordinary comeback from sex and corruption scandals since diving into the campaign in December, appeared to be leading in the Senate race, but Grillo's projected bloc of Senators would leave him well short of a majority.


Projections gave Bersani's center-left alliance a lead of less than one percentage point in the lower house. If confirmed, that would be enough to control the chamber because of election laws that guarantee a 54 percent majority to the party with the largest share of the vote.


In the Senate the picture was different. The latest projection from RAI state television showed Berlusconi's bloc winning 112 Senate seats, the center-left 105 and Grillo 64, with Monti languishing on only 20 after a failed campaign which never took off. The Senate majority is 158.


Berlusconi, a master politician and communicator, wooed voters with a blitz of television appearances and promises to refund a hated housing tax despite accusations from opponents that this was an impossible vote buying trick.


Grillo has attacked all sides in the campaign and ruled out a formal alliance with any group although it was not immediately known how he would react to his stunning success or how his supporters would behave in parliament.


DANGER OF NEW ELECTION


A bitter campaign, fought largely over economic issues, made some investors fear a return of the kind of debt crisis that took the euro zone close to disaster and brought the technocrat Monti to office, replacing Berlusconi, in 2011.


The projected results showed more than half of Italians had voted for the anti-euro platforms of Berlusconi and Grillo.


Officials from both center and left warned that the looming deadlock could make Italy ungovernable and force new elections.


A center-left government either alone or ruling with Monti had been seen by investors as the best guarantee of measures to combat a deep recession and stagnant growth in Italy, which is pivotal to stability in the currency union.


The benchmark spread between Italian 10-year bonds and their German equivalent widened from below 260 basis points to above 300 and the Italian share index lost all its previous gains after projections of the Senate result.


"These projections suggest that we are heading for an ungovernable situation", said Mario Secchi, a candidate for Monti's centrist movement.


Stefano Fassina, chief economic official for Bersani's center-left, said: "The scenario from the projections we have seen so far suggests there will be no stable government and we would need to return to the polls."


If the results are confirmed the only possibility looks like a "grand coalition" combining right and left, like the one Monti led for a year. But politicians said before the vote this could not work for long and would struggle to work decisively.


Monti helped save Italy from a debt crisis when Rome's borrowing costs were spiraling out of control, but few Italians now see him as the savior of the country, in its longest recession for 20 years.


Grillo's movement rode a huge wave of voter anger about both the pain of Monti's austerity program and a string of political and corporate scandals. It had particular appeal for a frustrated younger generation shut out of full-time jobs.


"I'm sick of the scandals and the stealing," said Paolo Gentile, a 49-year-old Rome lawyer who voted for 5-Star.


"We need some young, new people in parliament, not the old parties that are totally discredited."


Berlusconi, a billionaire media tycoon, exploited anger against Monti's austerity program, accusing him of being a puppet of German Chancellor Angela Merkel, but in many areas Grillo was a bigger beneficiary of public discontent.


Italy desperately needs a strong, reform-minded government to revive growth after two decades of stagnation and address problems ranging from record youth unemployment to a dysfunctional justice system and a bloated public sector.


Italians wrung their hands at prospects of an inconclusive result that will mean more delays to these reforms.


"It's a classic result. Typically Italian. It means the country is not united. It is an expression of a country that does not work. I knew this would happen," said 36-year-old Rome office worker Roberta Federica.


Another office worker, Elisabetta Carlotta, 46, shook her head in disbelief. "We can't go on like this," she said.


(Additional reporting by Stefano Bernabei, Steve Scherer, Gavin Jones, Naomi O'Leary and Giuseppe Fonte in Rome and Lisa Jucca in Milan; Writing by Barry Moody; Editing by Peter Graff)



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Football: Udinese put brakes on Napoli in Serie A






MILAN: Udinese held challengers Napoli to a scoreless draw on Monday to leave leaders Juventus with a six-point cushion at the top of Serie A.

Napoli had hoped to capitalise on the extra day's rest after their Europa League exit at the hands of Czech side Viktoria Plzen last Thursday to close the gap to four points.

However Walter Mazzarri's title challengers were left lamenting several missed chances on their way to dropping two points and boosting both Juve and third-placed AC Milan, who are now only seven points adrift.

The Partenopei underlined their intentions by starting with the attack-minded front trio of striker Edinson Cavani, Lorenzo Insigne and Marek Hamsik.

But the visitors were left frustrated after a first half in which Udinese seemed happy to sit back and defend and wait to counter-attack.

Early on Cavani failed to make contact despite a sly run towards goal when Giandomenico Mesto aimed in a cross.

Udinese did hit Napoli on the counter, but both Antonio Di Natale and Giovanni Pasquale sent their efforts high and wide respectively.

Napoli, however, had the momentum and after Gokhan Inler sent a long range effort over from long-range Hamsik missed the best chance of the half when he headed a long cross from the left straight at 'keeper Daniele Padelli.

Udinese started in more positive fashion after the break and came close just five minutes in although Argentine Roberto Pereyra wasted Antonio Di Natale's cross by firing into the stands from close range.

Napoli regained control but just couldn't finish the job despite a number of promising offensives, with Cavani spurning a late chance with 15 minutes on the clock after a great move down the left with Colombian Pablo Armero.

-AFP/ac



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Manmohan will visit UAE next month

NEW DELHI: Prime Minister Manmohan Singh will visit the United Arab Emirates (UAE) next month, government sources confirmed on Monday. This will be the first visit by an Indian PM to the Gulf country in 32 years.

The last visit was by Indira Gandhi in 1981. Singh will visit Abu Dhabi en route to Durban, where is scheduled to attend the BRICS summit in the fourth week of March.

Government has been contemplating a bilateral investment promotion and protection agreement with the UAE and it is possible that the pact will be signed during Singh's visit. India and the UAE have an annual trade volume of over $ 72 billion dollars.

Singh will also hope to address investor concerns there considering how Abu Dhabi-based telecom major Etisalat was forced to shut operations in India last year after the Supreme Court cancelled 122 telecom licences following the 2G scam. In fact, Etihad Airways, which had almost finalized a deal for picking up a 24% stake in Jet Airways, is now said to be doing a rethink because of what is routinely described by international agencies as unpredictable market conditions in India. According to sources, the UAE is insisting on signing the pact before the Etihad-Jet deal. The UAE is the 10th biggest investor in India in terms of FDI.

``Considering the size of the Indian expatriate community it is high time an Indian prime minister visited UAE,'' said a source confirming that the visit will take place just after the first part of the budget session.

The Indian expatriate community is the largest in the UAE, totaling around 2 million. According to foreign ministry data, about 20% of the community comprises professionally qualified personnel, another 20% are white-collar non-professionals and the rest are blue-collar workers. The presence of a large number of blue-collar workers has also forced India to develop effective grievance-redressal mechanisms for its workers. Then President Pratibha Patil had visited the UAE in 2010 during which the Gulf nation reaffirmed support for India's permanent membership in an expanded UN Security Council.

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Secret Vatican Dossier for 'Pope's Eyes Only'





Feb 25, 2013 9:05am


ROME – Pope Benedict XVI decided to keep secret the contents of an investigative report on the “Vatileaks” scandal, ruling that the only person who will get to see it will be the next pope.


The top secret dossier details the findings of an internal investigation the pope launch last April into the so-called Vatileaks affair, in which Benedict’s former butler leaked confidential documents stolen from the papal chambers.


Italian newspapers have claimed — without attribution — that the investigation revealed a sex and blackmail scandal inside the curia.


The Vatican spokesman today underscored that the contents of the dossier are known only to the pope and his investigators, three elderly prelates whom the Italian papers have nicknamed “the 007 cardinals.”


Pope Benedict met today with Cardinals Julian Herranz of Spain, Jozef Tomko of Slovakia, and Salvatore De Giorgi of Sicily in a private audience.


According to the Vatican, the pope thanked them for their work and expressed satisfaction with their investigation.


“Their work made it possible to detect, given the limitations and imperfections of the human factor of every institution, the generosity and dedication of those who work with uprightness and generosity in the Holy See,” read a Vatican statement.


The Vatican statement pointedly added: “The Holy Father has decided that the acts of this investigation, known only to himself, remain solely at the disposition of the new pope.”


Many here had expected the investigating cardinals, who are too old to participate in the conclave, would brief the voting cardinals about their findings.


Today Vatican officials clarified the investigating cardinals will be free to discuss their investigation with the other cardinals, as the voting members of the conclave seek to understand the challenges the next pope will face.


But the dossier itself will remain “For the Pope’s Eyes Only.”




SHOWS: World News






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China's Huawei claims world's fastest smartphone






BARCELONA: China's Huawei, the number three smartphone maker behind giants Samsung and Apple, unveiled Sunday a new mobile, the Ascend P2, which it claims is the fastest in the world.

Sharp-cornered and thinner than a pencil at 8.4 mm, the company said it can achieve speeds of 150 Mbps, fast enough to download a two-hour high-definition movie in less than five minutes.

The mobile, which has a 4.7-inch, high definition screen, has a powerful 1.5 GHz quad-core processor and is able to use the fourth-generation high speed mobile networks being rolled out worldwide.

Unveiling the device on the eve of the opening Monday of the four-day Mobile World Congress in Barcelona, Spain, the company said it was "the world's fastest smartphone," smashing all previous records.

Huawei said its phone surpassed top speeds of 100 Mbps for the fourth-generation network ready versions of Apple's flagship iPhone 5 and Samsung's Galaxy SIII.

The Ascend P2 will launch in France through Orange in June and is also expected to be available worldwide during the second quarter of 2013, it said.

"Ascend P2 downloads HD movies in minutes, and loads online videos, web pages, songs or e-Books in seconds," Huawei said in a company statement issued at the launch.

The phone, which includes a 13 megapixel camera, is the latest shot in Huawei's battle against the fast-growing market's titans Samsung and Apple.

Samsung and Apple accounted for more than half of all smartphone sales in the final quarter of 2012 -- 29.0 per cent for Samsung and 22.1 per cent for Apple -- according to research firm Strategy Analytics.

Behind Samsung and Apple, however, Chinese firms held the third, fourth and fifth spots -- with 5.3 per cent for Huawei, 4.7 per cent for ZTE and 4.4 per cent for Lenovo.

- AFP/jc



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Karunanidhi slams AIADMK, BJP over stand on Sethusamudram

CHENNAI: DMK Chief M Karunanidhi on Sunday called on the Centre to take steps to present a strong case before the Supreme Court on the Sethusamundram shipping channel project sought to be blocked by "communal forces".

Flaying the BJP and the AIADMK for their stand on the project, Karunanidhi said the national party, while in power, had proposed the alignment for the project which involved dredging of 'Ram Sethu', the mythical bridge believed to have been built by Lord Ram to cross over to Lanka. Now it is firmly opposed to the project.

"After considering various proposals over the route, the Vajpayee-led NDA government had decided to implement the project on alignment No 6 which involves the Ram Sethu, called Adam's Bridge. Forgetting that, it is now opposing dredging of Ram Sethu," he said.

The Pachauri Committee has said the shipping channel project is not viable on economic and ecological grounds. The government has rejected the report and maintained that it intends to pursue the project which will cut through the Adam's Bridge.

On the AIADMK chief J Jayalalithaa's demand to the prime minister that Ram Sethu be declared a national monument, Karunanidhi said she had claimed in 2005 that it was due to her efforts that preliminary work on the project was initiated in 1998 and that she had been instrumental in its taking shape.

The AIADMK had in its 2001 poll manifesto spoken in favour of the Sethusamudram project, he said, adding she had turned against it since she didn't want DMK to take the credit.

"Some communal forces had taken the issue to the apex court with a view to creating roadblocks," he said.

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FDA approves new targeted breast cancer drug


WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.


The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.


Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.


"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."


Cobleigh helped conduct the key studies of the drug at the Chicago facility.


The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.


The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.


Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.


FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.


Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.


FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer


Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.


Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.


Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.


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Pistorius' Brother Facing Own Homicide Trial












The attorney for Oscar Pistorius' family said today that the Olympian's brother is facing a culpable homicide charge relating to a 2008 road accident in which a motorcyclist was killed.


Carl Pistorius, who sat behind his younger brother, Oscar, every day at his bail hearing, will now face his own homicide trial for the accident five years ago, which his attorney, Kenny Oldwage, said he "deeply regrets."


Carl Pistorius is charged with culpable homicide, which refers to the unlawful negligent killing of another person. The charges were initially dropped, but were later reinstated, Oldwage said in a statement.


Full Coverage: Oscar Pistorius Case


Pistorius quietly appeared in court on Thursday, one day before his Paralympic gold-medalist brother was released on bail, Oldwage said. His next appearance is scheduled for the end of March.






Liza van Deventer/Foto24/Gallo Images/Getty Images











'Blade Runner' Murder Charges: Oscar Pistorius Out on Bail Watch Video











Oscar Pistorius Granted Bail in Murder Case Watch Video





It was the latest twist in a case that has drawn international attention, after 26-year-old Oscar Pistorius, a double amputee who ran in both the 2012 Olympic and Paralympic games, was charged with the premeditated murder of his model girlfriend, Reeva Steenkamp.


On Saturday, Carl Pistorius' Twitter handle was hacked, according to a family spokeswoman, prompting the Pistorius family to cancel their social media accounts.


Steenkamp's parents speak about the Valentine's Day shooting that ended their daughter's life in a sit-down interview on South African television tonight.


On Saturday, the model's father, Barry Steenkamp, told the Afrikaans-language Beeld newspaper that Pistorius will have to "live with his conscience" and will "suffer" if his story that he shot Steenkamp because he believed she was an intruder is false.


RELATED: Oscar Pistorius Case: Key Elements to the Murder Investigation


After a four-day long bail hearing, Pistorius was granted bail Friday by a South African magistrate.


The court set bail at about $113,000 (1 million rand) and June 4 as the date for Pistorius' next court appearance.


Pistoriuis is believed to be staying at his uncle's house as he awaits trial. As part of his bail conditions, Pistorius must give up all his guns, he cannot drink alcohol or return to the home where the shooting occurred, and he must check in with a police department twice a week.



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